Misconceptions on Peptide Synthesis


Since the mid 1960s, there has been a lot of development in the field of peptide synthesis, and a lot of methods have come into existence, with solid phase peptide synthesis being one of them. There is a lot still happening to refine the processes, discover new synthesis methods, and improve the overall quality of the products. In most cases, those in need of synthetic peptides can obtain them on readymade peptide synthesis schemes, and these include liquid phase synthesis, solid phase synthesis, and also large-scale production.

Most of the time, the commonly used method to produce peptides, is to simply purchase amino acids from some of the leading chemical producers in the world, then use the amino acids as a raw material for the production of synthetic peptides. During the fifties and sixties throughout the past century, most of peptides were obtained solely from animal organs. If you consider thymosin, for example, it used to be extracted from the thymus of a newborn calf, and then the thymus peptide was separated using shock separation technology. Peptide was greatly used for human immunity back in the day.

Currently, such peptides are not in use anymore due to the mad cow disease. The virus responsible for causing this disease has the ability to engulf the animal protein in the brain, and this can lead to the destruction of the brain’s tissues, nerves and brain cells. When the virus accesses the human body through injection, it becomes even more lethal than cancer and the patients who are unlucky to get it will soon enter the vegetative state or simply die.

For those who are just starting out in the world of peptides and peptide synthesis, it will be important to understand the principle of particular peptide synthesis, as well as other specific processes around the concept. You will have to know about things such as deprotection, resin swelling, and coupling as they are the basic terms and processes relating to peptide synthesis.